Vitae Pharmaceuticals Capabilities – Target to POC
Vitae Pharmaceuticals has the capabilities necessary to advance a program from the bench to the clinic.
Vitae Pharmaceuticals has the efficiency advantage of being small – allowing for intense focus on our core competencies of structure-based drug discovery and early development while leveraging external relationships in a virtual network for non-core expertise.
| Target | Lead Generation | Lead Optimization | Pre-Clinical | Clinical |
|---|---|---|---|---|
|
Protein cloning and expression Protein production 3D protein analysis (Apo) X-ray crystallography Assay development |
Structure based drug design Medicinal chemistry Synthetic chemistry (internal/external) Ligand X-ray crystallography In vitro select – metabolism In vitro safety In vivo PK (external) |
Structure based drug design Rapid analoging Ligand X-ray crystallography PK / PD / efficacy (external) |
ADME (internal/external) Pharmacology (external) Toxicology (external) Scale up (internal/external) Process chemistry (internal/external) Formulation development (external) |
Clinical strategy Protocol writing Ph 1/2 studies (clinical CRO’s) Biomarkers Functional and therapeutic area expert consultant networks |
As depicted here, Vitae Pharmaceuticals' capabilities are both broad and deep. They are based on technology, on people and on skill sets and processes that incorporate modern structure-based drug design and development.
Vitae Pharmaceuticals' capabilities begin with a broad skill set represented by its scientists including its founder, a Hall of Fame medicinal chemist who discovered six significant drugs that have gone on to become commercial successes and important therapeutics for patients; and its Chief Scientific Officer, who advanced multiple programs from the preclinical stage through human trials and helped develop multi-billion dollar pharmaceutical brands. And it expands in its reach and scope through the expertise of 45 scientists and a robust technology engine.